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Araki Y et al. Dihydropyrimidine dehydrogenase activity and thymidylate synthase level are associated with response to 5-fluorouracil in human colorectal cancer. Kurume Med J 2001;48:93-8. Abstract

Bajetta E et al. Activity and safety of capecitabine and irinotecan (CPT-11) in association as first line chemotherapy in advanced colorectal cancer (ACRC). Eur J Cancer 2001;37(Suppl 6):293. Abstract

Becouarn Y et al. Randomized multicenter phase II study comparing a combination of fluorouracil and folinic acid and alternating irinotecan and oxaliplatin with oxaliplatin and irinotecan in fluorouracil-pretreated metastatic colorectal cancer patients. J Clin Oncol 2001;19:4195-201. Abstract

Falcone A et al. Sequence effect of irinotecan and fluorouracil treatment on pharmacokinetics and toxicity in chemotherapy-naive metastatic colorectal cancer patients. J Clin Oncol 2001;19:3456-62. Abstract

Hoff PM et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study. J Clin Oncol 2001;19:2282-92. Abstract

Kerr DJ et al. CPT-11 in combination with capecitabine as first line chemotherapy for metastatic colorectal cancer (MCRC): Preliminary results of a phase I/II study. Eur J Cancer 2001;37(Suppl 6):296. Abstract

Saltz LB et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med 2000;343:905-14. Abstract

Scheithauer W et al. Randomized multicenter phase II trial of oxaliplatin plus irinotecan versus raltitrexed as first-line treatment in advanced colorectal cancer. J Clin Oncol 2002;20:165-72. Abstract

Schleucher N et al. Extended phase I study of capecitabine and weekly irinotecan as first-line chemotherapy in metastatic colorectal cancer. Eur J Cancer 2001;37(Suppl 6):290. Abstract

Twelves C et al. Capecitabine in combination with oxaliplatin as first line therapy for patients (pts) with advanced or metastatic colorectal cancer (ACRC): Preliminary results of an international multicenter phase II study. Eur J Cancer 2001;37(Suppl 6):272. Abstract

Van Cutsem E et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large phase III study. J Clin Oncol 2001;19:4097-106. Abstract

Zeuli M et al. Oxaliplatin and capecitabine in advanced colorectal cancer: A pilot study. Eur J Cancer 2001;37(Suppl 6):309. Abstract

Pharmaceutical agents discussed in this program

capecitabine Xeloda® Roche Laboratories, Inc.
leucovorin Wellcovorin® GlaxoSmithKline
irinotecan (CPT-11) Camptosar® Pharmacia Corporation
oxaliplatin Eloxatin® Sanofi-Synthelabo, Inc

 

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